Guosheng Wu

I joined the Spalding lab in September, 2003 after I finished my PhD study at the University of Illinois at Urbana. My general research interest lies in the developmental biology of Arabidopsis, especially in auxin biology related to seedling establishment.

I have been working to describe the functions of Multidrug Resistance (MDR) ABC transporter genes, also known as PGP or ABCB transporters, that are critical for auxin transport in plants. My research goal is to uncover the molecular-genetic controls of polar auxin transport streams and their physiological significance, especially related to light or gravity signaling.

The following are some representative publications highlighting my recent works:

Wu G, Otegui MS, Spalding EP (2010) The ER-localized TWD1 immunophilin is necessary for localization of multidrug resistance-like proteins required for polar auxin transport in Arabidopsis roots. Plant Cell 22: 3295-3304

Wu G, Cameron JN, Ljung K, Spalding EP (2010) A role for ABCB19-mediated polar auxin transport in seedling photomorphogenesis mediated by cryptochrome 1 and phytochrome B. Plant J 62:179-91

Lewis DR, Wu G, Ljung K, Spalding EP (2009) Auxin transport into cotyledons and cotyledon growth depend similarly on the ABCB19 Multidrug Resistance-like transporter. Plant J 60:91-101

Wu G, Ort DR (2008) Mutation in the cysteine bridge domain of the gamma-subunit affects light regulation of the ATP synthase but not photosynthesis or growth in Arabidopsis. Photosynthesis Research 97:185-93

Wu G, Ortiz-Flores G, Ortiz-Lopez A, Ort DR (2007) A point mutation in atpC1 raises the redox potential of the Arabidopsis chloroplast ATP synthase g- subunit above the range of thioredoxin modulation. J Biol Chem 282:36782-36789
This paper was featured in JBC's "Papers of the Week".

Wu G, Spalding EP (2007) Separate functions for nuclear and cytoplasmic pools of the cryptochrome 1 photoreceptor during photomorphogenesis of Arabidopsis seedlings. Proc Natl Acad Sci USA 104:18813-18818

Wu G, Lewis DR, Spalding EP (2007) Mutations in Arabidopsis Multidrug Resistance-Like ABC transporters separate the roles of acropetal and basipetal auxin transport in lateral root development. Plant Cell 19:1826-1837

Gong P, Wu G and Ort DR (2006) Slow dark deactivation of Arabidopsis chloroplast ATP synthase caused by a mutation in a nonplastidic SAC domain protein. Photosynthesis Research 88:133-142